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Homeopathy has long faced skepticism from the modern medical community, which claims that homeopathic medicines are mere placebos and that high dilutions are ineffective. However, scientific research provides insight into how homeopathy works even at ultra-high dilutions. The following information is sourced from the Faculty of Homeopathy, UK.
While homeopathy is based on the principle of similarity, its most debated aspect is the effectiveness of ultra-molecular dilutions. Avogadro’s Constant, which represents the number of atoms or molecules in a gram mole of a substance, is approximately 10²³. In homeopathic terms, this corresponds to a 23X or 12C dilution. Homeopathic preparations below this dilution contain trace amounts of the original substance, whereas ultra-molecular dilutions likely do not.
One hypothesis explaining the action of homeopathic dilutions is the “memory of water” effect. This suggests that under specific conditions, water can retain information about substances it previously encountered and transmit this information to pre-sensitized biological systems. Standard physico-chemical techniques—including thermoluminescence, Raman spectroscopy, and UV-VIS spectroscopy—have demonstrated significant changes in water’s physico-chemical properties based on its history. However, it remains to be proven whether these changes directly account for homeopathic effects in living organisms.
Another proposed mechanism involves molecular clustering in water solutions. Research indicates that as a solution becomes increasingly diluted, stable molecular clusters or ‘clumps’ of the original substance can form, persisting even at high dilutions. Additionally, the vigorous shaking process used in homeopathy, known as succussion, may generate nanobubbles that trap gaseous inclusions such as oxygen, nitrogen, carbon dioxide, and possibly remnants of the homeopathic source material.
A recent meta-analysis of 67 in-vitro biological experiments, published across 75 research studies, found that nearly 75% of replicated studies reported high-potency effects. However, no single positive result has been consistently reproducible across all studies.
One notable example is the human basophil degranulation test, which models the allergic response to antibodies. The earliest experiments suggested that ultra-molecular dilutions of anti-IgE inhibited degranulation, but these findings were not initially reproducible. Later studies using a modified method and ultra-molecular dilutions of histamine reported positive results. These findings have since been confirmed by independent laboratories and through multi-center experiments.
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