carewell homoeopathic fertility clinic

Maturation Arrest

Maturation Arrest is the cessation of complete differentiation of cells at an immature stage; in spermatogenic maturation arrest, the seminiferous tubules contain spermatocytes, but no sperms develop.

Complete maturation arrest: germ cell maturity ceases at a specific point frequently at primary spermatocyte level; sperm counts usually zero

•Incomplete maturation arrest: similar to complete but a few late spermatids are present in a few seminiferous tubules, some prefer the term hypospermatogenesis instead of incomplete maturation arrest

As sperm develop, they undergo a series of maturation steps. At any one of these steps, abnormalities may occur. Sperm are produced by repeated division of cells in small coiled tubules within the testes at a rate of appropriately 100 million per day. Sperm production is a lengthy process; from the beginning of division of the stem cell to the appearance of mature sperm in the semen takes about 3 months.

Testicular Failure

The main  cause of azoospermia is testicular failure, which is the inability of the testicles to produce enough mature sperm. Causes of testicular failure include chromosome problems, diseases of the testicle, and injury to the testicale. Undescended testicles at birth or frequent and heavy use of marijuana can also increase the risk of testicular failure. This can occur during any stage of sperm production. The testicle may not have the cells necessary that divide to become sperm cells, or the sperm may be unable to fully develop and mature.

Hormones are necessary for the testicles to produce sperm. The testicles produce sperm when they are stimulated by pituitary hormones. If there is an absence of these hormones, or a small amount of these hormones, sperm production can be affected. Men who take or have taken steroids may have affected the hormones necessary for sperm production.The function of the testes is dependent upon hormones from the pituitary gland – follicle stimulating hormone (FSH) and luteinizing hormone (LH). The level of these hormones rise during the early stages of puberty and stimulates testicular development. LH controls production of the male sex hormone testosterone which in turn is responsible for development of the genitals, beard and body hair, prostate and seminal vesicles, and also bone and muscle development and other aspects of masculine physique. If LH and FSH are deficient the testes do not develop properly. In contrast, if the testes are damaged directly, the levels of these hormones in the blood rise. Thus the measurement of LH, FSH and testosterone in blood helps in the diagnosis of testicular disorders.



There are effective medicines in homeopathy to stimulate the hypothalamus and pituitary and can normalize production of FSH, LH and testosterone


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